Custom Radiosynthesis & Radiolabeling

Custom Radiosynthesis & Radiolabeling

The most logical way to study the interaction between your specific molecule and the target receptor is to use a RADIO-labelled version. METIS Labs’ can provide you custom radiolabeling and custom radiosynthesis of your small molecules, peptides, antibodies and proteins.

High specific activity and retention of the molecular structure is essential for the success of radiometric assays such as

Receptor Ligand Binding

in vitro Autoradiography

ex vivo Autoradiography

in vivo receptor occupancy

Analysis of products is performed using methods including LC-MS, HPLC-Radiochemical Flow, HPLC-UV, TLC Radioscan and NMR.

Custom synthesis is an important part of our business. Often we subsidize the cost of custom synthesis for potentially new catalog products. Many of our exclusive products in our radiochemical catalog have been derived from custom syntheses. Built upon years of experience in a top pharmaceutical company our organic chemists provide world class expertise and integrated solutions to accelerate your drug development programs.

Physical Characteristics of Tritium [3H], Iodine-125 [125I] and Carbon-14 [14C]

Tritium [3H] Iodine-125 [125I] Carbon-14 [14C]
Visa - 3412 Beta Iodine-125 [125I] Carbon-14 [14C]
Half-life 12.43 years 60 days 5730 years
Energy (max) 0.0186 MeV 0.035 MeV 0.156 MeV
Decay Product 3He (stable) 125Te (stable) 14N (stable)
Range of beta particles 3-6 µm - 200-300 µm
Maximum Specific Activity 1.06 TBq/maton(28.76 Ci/maton) 80.9 TBq/maton(2186 Ci/maton) 2.31 GBq/mmol(62.5 mCi/mmol)
Efficiency of Measurement 40% (liquid scintillation) 75-90% (gamma counting) 70% (liquid scintillation)

We offer three different custom services

Radioiodination

Radioiodine ([125I]) is widely used in the preparation of tracers for sensitive immunoassays and other procedures for the detection...

Tritiation [3H] & Carbon Synthesis [14C]

METIS Labs can perform custom tritiation and carbon synthesis of small molecules for receptor binding, receptor occupancy and QWBA assays.

Case Studies