Quantitative Whole Body Autoradiography (QWBA)

Quantitative Whole Body Autoradiography (QWBA)

Quantitative whole-body autoradiography (QWBA) is a technique used to determine the distribution of radiolabeled novel compounds to various tissues and organs in laboratory animals as part of a comprehensive preclinical ADME strategy to address regulatory compliance needs.

QWBA can provide dosimetric calculations before human radiolabeled studies and can help evaluate compound interactions by observing changes in tissue distribution of a novel compound when co-administered with another drug. Investigation of novel compound affinity with the site of pharmacological action is essential for preclinical safety and toxicology assessments.

In addition to providing a quantitative measure of distribution, the high-resolution digital image obtained from a phosphorimager can be enhanced to provide greater detail of the distribution in the tissues or organ of interest.

QWBA Applications

Tissue distribution

Target organ/tissue validation

Correlation with histopathology

Placental transfer

Penetration of blood-brain barrier

Tumor penetration

Support of micronucleus test

Human dosimetry calculations

Dermal/ungual penetration

How We Work

Case Studies