QWBA can provide dosimetric calculations before human radiolabeled studies and can help evaluate compound interactions by observing changes in tissue distribution of a novel compound when co-administered with another drug. Investigation of novel compound affinity with the site of pharmacological action is essential for preclinical safety and toxicology assessments.
In addition to providing a quantitative measure of distribution, the high-resolution digital image obtained from a phosphorimager can be enhanced to provide greater detail of the distribution in the tissues or organ of interest.
Target organ/tissue validation
Correlation with histopathology
Penetration of blood-brain barrier
Support of micronucleus test
Human dosimetry calculations