888-295-7550 info@metislabs.com
services / Custom Radiosynthesis & Radiolabeling

Custom Radiosynthesis & Radiolabeling

Custom Radiosynthesis & Radiolabeling

The most logical way to study the interaction between your specific molecule and the target receptor is to use a RADIO-labelled version. METIS Labs’ can provide you custom radiolabeling and custom radiosynthesis of your small molecules, peptides, antibodies and proteins.

High specific activity and retention of the molecular structure is essential for the success of radiometric assays such as

  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Receptor Ligand Binding
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 in vitro Autoradiography
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 ex vivo Autoradiography
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 in vivo receptor occupancy

Analysis of products is performed using methods including LC-MS, HPLC-Radiochemical Flow, HPLC-UV, TLC Radioscan and NMR.

Custom synthesis is an important part of our business. Often we subsidize the cost of custom synthesis for potentially new catalog products. Many of our exclusive products in our radiochemical catalog have been derived from custom syntheses. Built upon years of experience in a top pharmaceutical company our organic chemists provide world class expertise and integrated solutions to accelerate your drug development programs.

Physical Characteristics of Tritium [3H], Iodine-125 [125I] and Carbon-14 [14C]

Tritium [3H] Iodine-125 [125I] Carbon-14 [14C]
Visa – 3412 Beta Iodine-125 [125I] Carbon-14 [14C]
Half-life 12.43 years 60 days 5730 years
Energy (max) 0.0186 MeV 0.035 MeV 0.156 MeV
Decay Product 3He (stable) 125Te (stable) 14N (stable)
Range of beta particles 3-6 µm 200-300 µm
Maximum Specific Activity 1.06 TBq/maton(28.76 Ci/maton) 80.9 TBq/maton(2186 Ci/maton) 2.31 GBq/mmol(62.5 mCi/mmol)
Efficiency of Measurement 40% (liquid scintillation) 75-90% (gamma counting) 70% (liquid scintillation)

Other Services In Custom Radiosynthesis & Radiolabeling

Case Studies

Compound Characterization

Compound Characterization

Compound Characterization Study Goal Determine ex vivo receptor occupancy of CMPDx at Orexin-1 (OX1) receptors using radiolabeled Orexin antagonist Created by potrace 1.10, written by Peter Selinger 2

View More
Compound Characterization 1

Compound Characterization 1

Compound Characterization Study Goal Determine ex vivo receptor occupancy of CMPDx at Orexin-1 (OX1) receptors using radiolabeled Orexin antagonist Created by potrace 1.10, written by Peter Selinger 2

View More

Call Us On

888-295-7550