888-295-7550 info@metislabs.com
services / in vivo ADME / Quantitative Whole Body Autoradiography (QWBA)

Quantitative Whole Body Autoradiography (QWBA)

Quantitative Whole Body Autoradiography (QWBA)

Quantitative whole-body autoradiography (QWBA) is a technique used to determine the distribution of radiolabeled novel compounds to various tissues and organs in laboratory animals as part of a comprehensive preclinical ADME strategy to address regulatory compliance needs.

QWBA can provide dosimetric calculations before human radiolabeled studies and can help evaluate compound interactions by observing changes in tissue distribution of a novel compound when co-administered with another drug. Investigation of novel compound affinity with the site of pharmacological action is essential for preclinical safety and toxicology assessments.

In addition to providing a quantitative measure of distribution, the high-resolution digital image obtained from a phosphorimager can be enhanced to provide greater detail of the distribution in the tissues or organ of interest.

QWBA Applications

  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Tissue distribution
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Target organ/tissue validation
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Correlation with histopathology
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Placental transfer
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Penetration of blood-brain barrier
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Tumor penetration
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Support of micronucleus test
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Human dosimetry calculations
  • Created by potrace 1.10, written by Peter Selinger 2001-2011 Dermal/ungual penetration

How We Work

Brainstorming

1

Research

2

Report

3

Case Studies

Compound Characterization

Compound Characterization

Compound Characterization Study Goal Determine ex vivo receptor occupancy of CMPDx at Orexin-1 (OX1) receptors using radiolabeled Orexin antagonist Created by potrace 1.10, written by Peter Selinger 2

View More
Compound Characterization 1

Compound Characterization 1

Compound Characterization Study Goal Determine ex vivo receptor occupancy of CMPDx at Orexin-1 (OX1) receptors using radiolabeled Orexin antagonist Created by potrace 1.10, written by Peter Selinger 2

View More

Call Us On

888-295-7550